Interestingly, the most resistant cell line Su-DHL10 which lacks Bax/Bak proteins [23], underwent 60% cell death in response to the combined treatment with both CQ and bortezomib (at 20 nM), indicating that blocking both autophagy and proteasome degradation is a potent therapeutic strategy to kill apoptosis-resistant lymphoma cells. The gene discussed is BAX; the disease is lymphoma.