Previous studies showed that ABC-DLBCL cell lines (OCI-Ly3 and OCI-Ly10) had high nuclear NF-κB DNA binding activity, constitutive I-κB kinase (IKK) activity and rapid I-κBα degradation that was not seen in GCB-DLBCL cell lines, such as Su-DHL-4. This evidence concerns the gene NFKBIA and diffuse large B-cell lymphoma.