CDH1 and neoplasm: Introduction of Snail factors into epithelial tumors results in cells that can disseminate from the primary tumor, are resistant to apoptosis, radiotherapy and chemotherapy, evade immune recognition, and exhibit markers of stem cells [19], [20], [21], [22]. Mechanistically, Snail proteins repress the expression of E-cadherin and components of adherens junctions, and Snail expression has been shown to correlate with tumor malignancy [17], [23], [24].