MUC4 and familial pancreatic carcinoma: Finally, MUC4 activity on tumour cell properties is most likely cell-specific (state of differentiation, tumour site origin: primary or metastatic) as we did not find the same results with moderately differentiated CAPAN-2 cells, which derive from a primary tumour [51] when compared with previous studies conducted in the poorly differentiated pancreatic cancer cell model HPAF-CD18, which derives from peritoneal ascitic fluid [52].