GPT and adrenal gland hyperfunction: All dogs assigned to the HC group developed clinical signs of hypercortisolism, such as polyuria, polydipsia and skin changes (atrophy of abdominal skin with phlebectasia, no regrowth of clipped haircoat, comedones, ecchymose) and complementary laboratory changes (increased alkaline phosphatase and alanine aminotransferase, ALT).