The primary network identified with the most relevance to E2+CyP4, with a network score of 36, includes a different set of 13 focus molecules (Apba1, Apbb1, Bace1, Icam1, Igf1, Mfn2, Nr1h3, Plcg2, Ppargc1b, Psen2, Sirt1, Slc25a4, Slc2a3; all of these genes were significantly regulated by E2+CyP4), and is functionally linked to gene expression, genetic disorder and also neurological disease (Fig. 4). This evidence concerns the gene PSEN2 and nervous system disorder.