The primary network identified with the most relevance to E2+CoP4, with a network score of 17, includes 7 focus molecules (Dnm1l, Galc, Hadh, Mfn1, Pdha1, Plcb4, Prdx5; all of these genes were significantly regulated by E2+CoP4), and is functionally connected to cellular compromise, changes in cell morphology and neurological disease. Here, PLCB4 is linked to nervous system disorder.