The relationship between the NO signal and FoxO has been pointed out in a report on a tail suspension-induced model of muscle atrophy, where nNOS-NO is suggested to induce muscle atrophy by upregulating the muscle-specific E3 ubiquitin ligases MuRF-1 and atrogin-1/MAFbx through FoxO activation. The gene discussed is TRIM63; the disease is Atrophy.