Multiple genetic CD variants have already been specifically associated with small intestinal involvement and most of the involved genes are important in the specialized cell's biology [7]: the Wnt transcription factor TCF7L2[24], NOD2[23], [40], ATG16L1[41], [42], XBP1[43] and very recently the potassium intermediate/small conductance calcium-activated channel KCNN4[44]. This evidence concerns the gene NOD2 and Cowden disease.