Phosphorylation of eIF4E was greatly enhanced in lymphomas from tPTEN−/− mice compared with lymphoid tissues of wild-type mice, but was abolished in lymphomas of tPten−/−; Mnk1/2-double knock-out mice, confirming that Mnk1 and Mnk2 kinase activity are essential for eIF4E phosphorylation in transformed cells. The gene discussed is EIF4E; the disease is lymphoma.