APOE and atherosclerosis: Accelerated atherosclerosis has been described in apolipoprotein E (ApoE)–deficient mice with either the gld or lpr mutation (4, 6, 8), and in bone marrow chimeras of gld mice transplanted into low-density lipoprotein (LDL) receptor–deficient (Ldlr−/−) mice (gld→Ldlr−/−) (7).