Radiation chimeras using the triple-congenic lupus mouse strain B6.Sle1.2.3 transplanted into Ldlr−/− mice (Sle1.2.3→Ldlr−/−) also showed increased atherosclerosis, which was thought to be due to systemic activation of B and T cells (5). Here, LDLR is linked to systemic lupus erythematosus.