LDLR and hyperlipidemia: In the high-fat diet group, however, no significant differences in the levels of anti–MDA-LDL antibodies of any isotype were detected between Ldlr−/− and Sle16.Ldlr−/− mice (Figure 3B), which could be mainly attributed to the increased levels of anti–ox-LDL antibodies in Ldlr−/− mice in response to the elevated hyperlipidemia driven by the high-fat diet, as has been previously reported (23).