Our results confirm that hypogalactosylation of IgG (assessed in our present study via the proxy measure sG0/G1) is prominent in patients with RA and improves with therapy, but they neither support the use of the sG0/G1 index as a guide to choosing between MTX and TNF inhibitors nor suggest a differential effect of these agents on IgG galactosylation. The gene discussed is TNF; the disease is rheumatoid arthritis.