Furthermore, as shown in Table 2, some modifiable risk factors targeted by the multifactorial treatment were lower in patients with high NT-proBNP (cholesterol, bloodpressure but not haemoglobinA1c), where as the non-modifiable risk factors such as diabetes duration, plasma creatinine and signs of peripheral artery disease were higher in patients with high NT-proBNP. The gene discussed is NPPB; the disease is peripheral arterial disease.