In spite of the fact that we do not find a significant association, our results are rather similar to those of Nakamura et al., as we found MGMT promoter hypermethylation in 15% primary glioblastomas, 50% secondary glioblastomas (2 of 4 samples analyzed), and 33% low-grade diffuse astrocytomas. Here, MGMT is linked to diffuse astrocytoma.