A recent report has found an increase of promoter hypermethylation in CALCA and CDH1 genes in high-grade astrocytomas, but they did not see any remarkable methylation frequency of other classical tumor suppressor genes, such as p14ARF, RB1, CDKN2B, or APC [22]. Here, CDKN2B is linked to astrocytoma (excluding glioblastoma).