RASSF1 and Familial prostate cancer: Finally, recent reports have pointed at the RASSF1A gene, on 3p21.3 [15], as an important tumor suppressor gene inactivated in several neoplasms, such as NSCLC, melanoma, breast, kidney, bladder, and prostate cancer and in some pediatric tumors, like medulloblastoma, neuroblastoma, and Wilms' tumor [5].