PTPN1 and hereditary clear cell renal cell carcinoma: Furthermore, a recent study which demonstrated that HIF binds to the PTP1B promoter and reduces PTP1B expression, and proposed that there was a HIF-regulated VHL-PTP1B-Src signaling axis in renal cell carcinoma (RCC) cells, suggests that there is a relationship between HIF-1 expression and PTP1B signaling [50].