ASAH1 and cancer: Notable examples include the subunit 20 S of the proteasome [6], which is inhibited by the anti-cancer drug bortezomib [7], N-acylethanolamine-hydrolyzing acid amidase (NAAA) [8], a potential target for anti-inflammatory and analgesic drugs [9], and acid ceramidase (AC) [10], a potential target for cancer chemosensitizing agents [11].