Death receptors of the tumor necrosis factor receptor (TNF) superfamily such as Fas receptor (Apo1/CD95), death receptor 4/TNF-Related apoptosis-Inducing ligand receptor 1 (DR4/TRAIL-R1), DR5 (TRAIL-R2), TNF-R1, and lymphotoxin-beta receptor (LTβR), are capable of inducing apoptotic signals into tumor cells following ligation with cognate death ligands from anti-tumor immune cells [27]–[32]. The gene discussed is TNF; the disease is neoplasm.