TNFRSF10A and Miyoshi myopathy: Although bone marrow stromal cells and osteoclasts create a microenvironment which confers resistance against apoptosis in MM cells, TACE inhibition is able to restore cell surface DR4 expression in MM cells even in the presence of bone marrow stromal cells or osteoclasts and enhance the cytotoxic effects of an agonistic antibody against DR4 on MM cells (Figures 5B and 5C).