Up-modulation of surface DR4 levels by the TAPI-0 treatment were also obtained in other MM cell lines, MM.1S, KMS12, TSPC-1, UTMC-2 and OPC, primary MM cells, leukemic cell lines, HL-60, and MD-MB-231 breast cancer cell line (Figure 2B). This evidence concerns the gene TNFRSF10A and breast carcinoma.