The anti-DR4 agonistic antibody R1-B12 was able to induce cell death in MM cells in the presence of bone marrow stromal cells (Figure 5C), although bone marrow stromal cells are known to secrete a large amount of osteoprotegerin, a TRAIL inhibitor [14], [15]; TACE inhibition by TAPI-0 further enhanced the DR4-mediated cell death with the antibody (Figure 5C). This evidence concerns the gene ADAM17 and Miyoshi myopathy.