These genes were significantly upregulated in the group 2 DIPGs relative to the group 1 tumours (GSEA analysis: enrichment score 0.56, FDRq = 0.039, p nominal = 0.034), together with the master epithelial-mesenchymal transition regulators, SNAI1 and SNAI2/Slug genes (Figure S3A). This evidence concerns the gene SNAI2 and neoplasm.