The gene expression profile of group 1 DIPG was significantly enriched for the gene set describing the signature of PDGFRA amplified gliomas described in the TCGA [24] and in children [8] (GSEA analysis: enrichment score 0.59, FDRq = 0.038, p nominal = 0.052) (Figure 5A). Here, PDGFRA is linked to glioma.