A subset of 7 transcription factors (STAT3, BHLHE40, CEBPA and B, RUNX1, FOSL2 and ZNF238) controlled most genes of the mesenchymal signature of gliomas; all but ZNF238 were significantly upregulated in the group 2 tumours compared to the other DIPG (Figure 3B). The gene discussed is BHLHE40; the disease is central nervous system cancer.