PDGFRA and cancer: In a recent study of the ‘Innovative Therapies in Children with Cancer’ consortium, where imatinib was only given to patients with proven PDGFRA, PDGFRB or KIT over expression determined by immunochemistry [20], one child with recurrent DIPG harboring PDGFRA expression in 50% of the cells in the biopsy showed a sustained objective response (minus 31% for tumor size) for a period of ten months.