AKT1 and early-onset autosomal dominant Alzheimer disease: In this respect, EPO through Wnt1 governs early and late apoptotic Aβ microglial injury through non-traditional canonical and non-canonical pathways that involve the integration of the PI 3-K/Akt1 pathways, mTOR, and mitochondrial related signaling of Bad, Bax, and Bcl-xL.Future studies that further elucidate the pathways of cell toxicity for microglia during Aβ exposure may open new approaches for previously unrecognized strategies against Alzheimer's disease and other degenerative disorders.