PICALM and Alzheimer disease: In addition, genome-wide association studies (GWAS) of large case-control datasets have identified significant association between late-onset AD and SNPs in CLU, PICALM, BIN1, CR1, MS4A4/MS4A6E, CD2AP, CD33, EPHA1, and ABCA7 (Harold et al. 2009; Lambert et al. 2009; Carrasquillo et al. 2010; Hollingworth et al. 2011; Naj et al. 2011).