In AD case RX1107 (age at onset 88), we detected a 2.9 Mb deletion on chromosome 7q35-q36.1 (Figure S2C) that disrupts the CNTNAP2 gene encoding the contactin-associated protein-like 2 protein, a member of the neurexin family that mediates interactions between neurons and glial cells. The gene discussed is CNTNAP2; the disease is Alzheimer disease.