Whereas, prior to this report, there was no experimental literature addressing glypicans’ role in behavior, there are reports of glypicans being involved in human psychiatric conditions: GPC6 is associated with a neuroticism using an age-by-SNP interaction model (Calboli et al. 2010), and GPC1 is a member of a schizophrenia gene network derived from a gene set enrichment analysis of GWA data (Potkin et al. 2010). This evidence concerns the gene GPC6 and schizophrenia.