Detailed comparison of our animals shows that although both transgenic models overexpress the transcriptional active N-terminal domain of SREBP-1a in the liver to a comparable degree, overexpressing of the functional SREBP-1a wild type shows a vast accumulation of lipids in the liver including obesity and insulin resistance, whereas the phosphorylation deficient alb–SREBP–1aΔP mice is protected. This evidence concerns the gene ALB and obesity due to melanocortin 4 receptor deficiency.