JAK2 and acute myeloid leukemia: TG101209 is a potent and selective inhibitor of JAK2 (IC50 = 6 nM) that induces cell cycle arrest and apoptosis in Ba/F3 cells expressing the JAK2V617F mutation (IC50 = 170 nM) and in JAK2V617F-expressing acute myeloid leukemia cells through the inhibition of pJAK2V617F and pSTAT5 [19].