In agreement it has been shown in an animal model, that alterations in the locus of the wnt5a, the JNK1 and the PKC-delta gene are associated with obesity, suggesting that wnt5a acts as an important anti-adipogenic factor not only in cell culture systems but also in a whole body organism [26]. The gene discussed is MAPK8; the disease is obesity due to melanocortin 4 receptor deficiency.