A multivariate analysis confirmed that despite the strong prognostic power of the MammaPrint profile, the CTC-profile added prognostic information with respect to disease-free survival, which was not only independent of the MammaPrint test, but also independent of tumor size, tumor grade, hormone receptor status, HER2/NEU status, and age (Table 2B). The gene discussed is NR4A1; the disease is neoplasm.