These gene networks included MYH6, ICAM5, KDR, CDH4, and AKAP5, which are important for regulating cellular elongation and filopodia extension to enable cellular mobility, as well as NR2E1 whose gene product interacts with the fibronectin matrix during cellular migration, in addition to WISP1 and PAX3 which have been implicated in the epithelial-to-mesenchymal (EMT) transition important for the distant spread of micrometastatic tumor cells. This evidence concerns the gene CCN4 and neoplasm.