We found that polymorphisms in Dectin-1 (rs3901533 and rs7309123) and DC-SIGN (rs4804800, rs11465384, rs7248637 and rs7252229) were associated with an increased risk to develop IPA infection, which points towards their critical involvement in the pathogenesis of this invasive fungal infection. The gene discussed is CLEC7A; the disease is fungal infectious disease.