Therefore, in this study we examined As2O3 exerts antimyeloma effects involving in activity toward cytoplasmic substrates α-tubulin and Hsp90 of HDAC6, IKK complex, and then the direct phosphorylation of p65 on NF-κB signaling pathway, which may provide a novel molecular basis and rationale for the use of As2O3 in MM treatment. The gene discussed is HDAC6; the disease is Miyoshi myopathy.