While Ehrmann et al.[7], Gonzalez et al.[8], [9] and Vollmert et al.[15] reported association of CAPN10 with PCOS and quantitative measures such as fasting insulin, blood glucose levels related to T2DM, Escobar-Morreale et al.[10] reported an association of CAPN10 polymorphism with hirsutism. Here, INS is linked to polycystic ovary syndrome.