We mapped several single amino acid polymorphisms leading to significantly enhanced capacity for NF-κB activation compared to B95-8 LMP1 and used samples from the Swiss HIV Cohort Study (SHCS) to evaluate the importance of LMP1 polymorphisms relevant to NF-κB activation in the etiology of EBV-associated HL. The gene discussed is PDLIM7; the disease is Hodgkins lymphoma.