CAO LMP1, a variant isolated from a NPC, was found to have increased potential to transform rodent fibroblasts and to induce tumors in nude mice, when compared to B95-8 LMP1 [14], leading to the hypothesis that polymorphisms within LMP1 gene influences the susceptibility to develop EBV-associated tumors. The gene discussed is PDLIM7; the disease is nasopharyngeal carcinoma.