HE3286 exhibits anti-inflammatory and insulin sensitizing activities in preclinical db/db and ob/ob mouse, fa/fa ZDF rat models of diabetes [10], [16], and in a rare example of species translation for sterols, in contrast to DHEA or β-AET, HE3286 is active in impaired glucose tolerant and type 2 diabetes mellitus human subjects [17]. Here, INS is linked to diabetes mellitus.