AGTR1 and endothelial dysfunction: Since angiotensin II is a strong activator of vascular oxidative stress via AT1 receptor and an inducer of endothelial dysfunction, it is likely that the protective effect of the RWPs treatment on aging-related endothelial dysfunction is due, at least in part, to its ability to normalize the expression of angiotensin II and AT1 receptors in the mesenteric arterial wall of middle-aged rats.