In accord with previous reports of beneficial cellular neuroprotective actions of GLP-1R activation translating to improvements in animal models of stroke [15], [18], PD [15], [19]–[21], AD [17], [23], [45], [46] and Huntington's disease [47], a clear amelioration of neuronal loss was evident by immunohistochemical analyses within the ventral horns of the lumbar spinal cord of Ex-4 treated SOD1 (G93A) mice. The gene discussed is SOD1; the disease is Stroke.