SOD1 and amyotrophic lateral sclerosis: Our previous study determined that when running wheels are provided in each mouse's cage, presymptomatic SOD1 (G93A) mice are more active runners (15–20 km/day) than age-matched control WT non-ALS (B6SJL-Tg(SOD1)2Gur/J) mice (7–9 km/day) [31].