RTN4 and lung cancer: One important exception is SBTBN1 and RTN4 within cTOH3/aTOH1 (2p16.3–16.1), where over-expression occurs almost exclusively in controls relative to lung-cancer cases, irrespective of smoking status (OR = 0.000 and 0.08, p<0.0001; Table 3, Figures 2A and 4).