Accordingly to these results, prior studies have also indicated that a progressive increase of the expression and/or activation of the individual biomarker EGFR, pAkt, NF-κB p65 or MIC-1 often occurred in PC stem/progenitor cells and their progenies during the PC progression to AI, invasive and metastatic disease states [15], [16], [18]–[21], [23], [25]–[27], [30]–[39],[52]. The gene discussed is EGFR; the disease is metastatic neoplasm.