Importantly, a positive immunostaining varying from moderate to strong, within the cytoplasm and near the membrane or in nuclei was also detected for EGFR, Ser473-pAkt, NF-κB p65 and MIC-1 in PC cells in 80–100% of bone metastasis tissues analyzed from 30 PC patients (Gleason scores = 6–10) (Figure 3; Table 1). Here, EGFR is linked to pachyonychia congenita.