EGFR and pachyonychia congenita: Importantly, the results have also indicated that Ser473-pAkt, NF-κB p65 and MIC-1 were co-expressed with EGFR in the same subset corresponding at about 54–62% of PC tissue specimens analyzed suggesting that these oncogenic signaling elements may all cooperate to promote the malignant transformation of PC epithelial cells during disease progression to a locally advanced disease state (Table 1).