More specifically, the characterization of PC cells and animal models relevant to prostate carcinogenesis has indicated that the persistent activation of EGFR and PI3K/Akt in PC cells with stem cell-like features may contribute to their high self-renewal and tumorigenic capacities, treatment resistance and tumor re-growth [13]–[15], [21], [58], [72]–[74]. The gene discussed is AKT1; the disease is pachyonychia congenita.