Consistent with this, our recent works combined with several prior studies have revealed that the down-regulation of the expression and/or activity of EGFR, PI3K/Akt, NF-κB or MIC-1 signaling element resulted in growth inhibition and a high rate of apoptotic death of androgen-dependent, AI and metastatic PC cell lines, including PC stem/progenitor cells [34], [36], [38], [58], [75], [76], [79], [80]. This evidence concerns the gene AKT1 and pachyonychia congenita.