EGFR and pachyonychia congenita: Data from immunhistochemical analyses in the present investigation have indicated that EGFR, pAkt, NF-κB p65 and MIC-1 were overexpressed in the same subset of localized PC tissue specimens as compared to adjacent and normal prostatic tissues during PC progression to locally advanced disease as well as in bone metastasis specimens from PC patients (Figures 1, 2, 3; Table 1).