The present investigation was undertaken to determine the clinical relevance of using a combination of multiple deregulated oncogenic products, including EGFR, the phosphorylated form of Akt, NF-κB p65 and MIC-1 as molecular biomarkers to predict the risk of PC progression to locally advanced tumor and therapeutic targets to eradicate the total PC cell mass. This evidence concerns the gene AKT1 and pachyonychia congenita.