NFKB1 and pachyonychia congenita: It has also been reported that a treatment with the sesquiterpene lactone, partenolide, of parental and CD44high and CD44−/low PC cell fractions isolated from metastatic cell lines (DU145, PC3, VCAP and LAPC4) and primary PC tumor cells induced cytotoxic effects in vitro through an inhibition of NF-κB and Src-related signaling components and inhibited the tumor growth of CD44high DU145 cell xenograft models in vivo[80].