More particularly, a weak cytoplasmic and membrane immunostaining for the EGFR protein were detected only in a small number of basal and luminal prostatic epithelial cells in non-malignant prostatic tissues while its expression varied from moderate to strong within the cytoplasm and at the membrane respectively, in the malignant epithelial cells localized in the intermediate and luminal compartments in a subset of primary prostatic adenocarcinoma specimens (Figure 1a). This evidence concerns the gene EGFR and prostate adenocarcinoma.