It has also been shown that the enhanced expression and constitutive activation of NF-κB, which may be induced through diverse growth factor cascades, including EGFR/PI3K/Akt and chemotherapeutic drugs such as docetaxel in PC cells, may result in an increase of the expression levels of numerous oncogenic products and anti-apoptotic factors [22], [24]–[26], [30], [75], [76]. This evidence concerns the gene EGFR and pachyonychia congenita.