Given the strong correlation to transcriptional reprogramming in response to infection with the hemibiotroph Pseudomonas syringae pathovar tomato DC3000 (DC3000) [43], [62], we hypothesised that the constitutive up-regulation of pathogen-responsive genes observed in NMD-mutant plants may confer resistance to pathogens. The gene discussed is PLA1A; the disease is infection.