Some genes representing the KEGG pathway “Pathways in cancer” (Pdgfra, Pdgfrb, Vegfa, PPP3ca, EphB2 and Prkcn) and the gene ontology term “regulation of transmission of nerve impulses” (Bdnf, Ngfb, Klk8 and Edn1) were also included (Fig. 4). The gene discussed is EDN1; the disease is cancer.