TARDBP and neurodegenerative disease: In the present study we set out to investigate specifically the role of aggregation of full length TDP-43 and of an N-terminally truncated and disease-associated fragment, TDP-25, in causing neurodegeneration by upregulation of molecular chaperones, the inherent machinery of all biological systems that combats misfolding and aggregation; it is well established that molecular chaperones are able to inhibit the aggregation of proteins associated with neurodegenerative diseases [7], [8].