ALB and neoplasm: Our preliminary in vitro experiments showed that it is not easy to reproduce the lifetime “binding” effect in cell cultures, probably because it is not simply binding to HER2 receptors per se that results in smaller lifetimes, but a combination of several processes, for example, involving the intermediate binding of the probe to blood albumin in circulation [39] with subsequent dissociation of specific probe inside the tumor from blood albumin through binding to HER2 receptors.