Analogous arrangements were observed in BCC, with Wnt5a being most strongly expressed at the leading edge, as well as in tumor-associated stroma (figure 5, left panels), while Fzd3 showed polarised expression within the tumor (figure 5, top middle), or in Fzd3-positive nests (white arrow heads). This evidence concerns the gene WNT5A and skin basal cell carcinoma.