Common alterations in non-small cell lung cancer (NSCLC), the most prevalent form of lung cancer, include mutations in K-Ras, overexpression of epidermal growth factor receptor (EGFR) and Bcl2, as well as inactivation/down-regulation of p53, Rb, and Pten tumor suppressor genes [3]. Here, RB1 is linked to non-small cell lung carcinoma.