KCNQ1 and long QT syndrome 1: As a pore-forming subunit of the IKs channel, decreased KCNQ1 protein levels could lead to a rapid decrease in IKs current, which has been well documented in human Romano-Ward Syndrome (LQT1 subtype) gene research [23] and in ion channel subunit remodeling research in animals exposed to long term arrhythmias [24].