CTNNB1 and neoplasm: CTNNB1 mutations were significantly associated with low tumor grade: grade 1, 59/243, (24%); grade 2, 25/149 (17%); grade 3, 4/62 (6%) (p = 0.0027, two-tailed Fisher's exact test) and FGFR2 mutations showed a trend towards an association with grade (grade 1, 29/249 (12%); grade 2 17/152 (11%); grade 3, 2/65 (3%) (p = 0.10) (Table S6).