Similar to cancer cells, the concentration of ROS was significantly increased in lal−/− bone marrow MDSCs (Figure 2B), which was accompanied by up-regulation of nitric oxide/ROS production genes (Figure 2A), glutathione peroxidase/glutathione reductase genes, and glucose 6-phosphate dehydrogenase gene (Table S2). This evidence concerns the gene G6PD and cancer.