HSD11B1 and obesity due to melanocortin 4 receptor deficiency: This module contained three of seven reported genes (C3AR1, HSD11B1 and CD68) with a highly significant MM (MM>0.75) from a previously identified macrophage-enriched metabolic network in subcutaneous adipose tissue in humans and mice that was associated with obesity-related traits and enriched for inflammatory response and macrophage activation pathway [11] (Table S3).