To examine the function of a single homologue of CDC20/CDH1 (termed CDC20 for simplicity) in the complex life-cycle of Plasmodium we used a rodent malaria model, P. berghei (Pb) in laboratory mice, which is very amenable to analysis by reverse genetics and where the entire life cycle, including within the mosquito vector, can be analysed. This evidence concerns the gene CDH1 and malaria.