One day post Ye infection the levels of the proinflammatory cytokines IL-6, IFN-γ, and IL-12p40 were 2 to 10-fold increased in sera from control mice compared to infected DC-depleted mice or mice without infection, indicating that DCs promote the production of these proinflammatory mediators upon Ye infection (Figure 1D). This evidence concerns the gene IL6 and infection.