The beneficial effect of the early CD8+ priming on the immunodominant low-precursor responses like the DbNP366-specific population following influenza infection at the extreme age was most striking when the relative contributions of particular antigen-specific CD8+ T cells were analysed based on total cell numbers (Figure 2, calculations based on Figure 1 for immunodominant DbNP366+CD8+ and DbPA224+CD8+ pools, and data not shown for subdominant DbPB1703+CD8+ and KbPB1-F262+CD8+ populations). The gene discussed is CD8A; the disease is influenza.