Whilst a previous study [42] suggested that age-related clonal TCR attrition is more prevalent for the low precursor frequency DbNP366+CD8+ repertoire, we found a greater reduction in the numbers of DbPA224+CD8+ (down 60.8%) versus DbNP366+CD8+ (down 34.9%)-specific nucleotide clonotypes per mouse recovered following primary infection of older mice (Tables 1 and 2). The gene discussed is CD8A; the disease is infection.