In this context, about a quarter of the neurons engage in Phase I as judged by VP16 and ICP27 fluorescence, but it seems likely that a much smaller number advance into Phase II as signified by either the presence of nuclear VP16 (this study) or the accumulation of true-late protein Us11 (Us11-GFP) in the presence of a compound that prevents secondary infection [14]. The gene discussed is RPS14; the disease is infection.