TP53 and Cowden syndrome 1: The deregulation of p53 and the consequent enhanced apoptotic response, in the absence of the CSB protein, gives rise to pronounced cell fragility when cells are exposed to stress of broad nature and can potentially explain the multiple degenerative problems including central nervous system degeneration, premature arterio-sclerosis, progressive joint deformities and loss of subcutaneous fat, in CS patients.