THBS1 and Wilson disease: We found a significant downregulation of THBS1 and CTGF in MYC-amplified AS in comparison with MYC-unamplified AS (THBS1: fold change = 0.15, P = 0.02; CTGF: fold change = 0.18; P = 0.06), other vascular tumors (THBS1: fold change = 0.20, P = 0.004; CTGF: fold change = 0.16; P = 0.02) and WD/DDLPS (THBS1: fold change = 0.19, P = 0.004; CTGF: fold change = 0.21; P = 0.05) (Fig. 4).