These miRNAs have been shown to mediate the proangiogenic effect of MYC by decreasing the THBS1 (particularly for miR-19a) and CTGF mRNA (particularly for miR-18a) half-life, thereby promoting tumor growth in vivo in a mouse colon carcinoma model (Dews et al., 2006). This evidence concerns the gene THBS1 and colon carcinoma.