According to each high-risk group, mutation of BRCA1 and BRCA2 genes were identified in 53 (8.5%) of 625 early onset patients, in 22 (17.7%) of 124 patients with bilateral breast cancer, in 3 (50.0%) of 6 patients with breast and ovarian cancer, in 1 (5.9%) of 17 male breast cancer patients, in 5 (7.6%) of 66 patients with cancer of multiple organs including breast, and in 19 (27.1%) of 79 patients having two or more of these high risks (Table 2). The gene discussed is BRCA2; the disease is breast cancer.